Illicit drugs made from plants (e.g., cocaine, heroin) are being replaced in some national drug markets by those that are synthesized (e.g., methamphetamine, fentanyl). The U.S. has had a parallel experience in the past decade with the rise of illicit consumption of synthetic opioids and cannabinoids. If illicit drug markets continue to separate from an agricultural base, it would upend traditional understandings of drug markets and drug policy.
In the context of a fast changing and well documented market in legal highs, the case of khat (Catha edulis) provides an interesting anomaly. It is first of all a plant-based substance that undergoes minimal transformation or processing in the journey from farm to market. Secondly, khat has been consumed for hundreds if not thousands of years in the highlands of Eastern Africa and Southern Arabia. In European countries, khat use was first observed during the 1980s, but has only attracted wider attention in recent years.