Remarkable drug policy developments are taking place in Latin America. This is not only at the level of political debate, but is also reflected in actual legislative changes in a number of countries. All in all there is an undeniable regional trend of moving away from the ‘war on drugs’. This briefing ex­plains the background to the opening of the drug policy debate in the region, summa­rises the most relevant aspects of the on­going drug law reforms in some countries, and makes a series of recommendations that could help to move the debate forward in a productive manner.